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Sildenafil is really a potent and selective inhibitor of cGMP certain phosphodiesterase form 5 (PDE5) within the corpus cavernosum, in which PDE5 is to blame for degradation of cGMP. Sildenafil incorporates a peripheral site of motion on erections. Sildenafil has no immediate relaxant effect on isolated human corpus cavernosum but potently improves